Models & Sculpts

The Inflammatory Response

The Inflammatory Response CLIENT David Rini YEAR 2023 MEDIA Cinema 4D, Adobe Photoshop, Adobe After Effects DESCRIPTION This animation depicts the physiological and molecular events that occur during an acute inflammatory response through a sequential narrative. It illustrates the key cellular components of inflammation and symptoms that accompany it. By linking these mechanisms to recognizable physiological reactions, the animation provides an overview of inflammation at an appropriate level for the target audience. The narrative uses a pixel game-inspired scene as a framing device to introduce the narrative to viewers with playful, recognizable imagery. The molecular environment is stylized as a simplified, aqueous environment to reduce cognitive load. Storyboards Ahead of creating the animation, I created storyboard sketches in Procreate to establish the content and flow of the video. Process I created my 3D scenes in Cinema4D, while I created frames for the 2D scenes in Photoshop to mimic the look of a pixel game. The final video was created in After Effects, where I put together the animations, voice over, and sound effects.

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Engineering Immunocytokines

Engineering immunocytokines to promote anti-tumor activity CLIENT Fabian de Kok-Mercado, Lydia Gregg, Jamie Spangler YEAR 2023 MEDIA PyMOL, Cinema 4D, Adobe Photoshop DESCRIPTION The engineered F10 immunocytokine is composed of an F10 antibody linked to interleukin-2 (IL-2). The structure of the immunocytokine favors the binding of IL-2 to the IL-2 receptor heterodimer on e ector T cells, which triggers a pathway that promotes antitumor activity. This illustration depicts this interaction in an immersive tumor cell environment. The illustration was created for a journal cover, and molecule colors were chosen to align with the accompanying paper’s figure legend. The anatomy of the immunocytokine is labeled, as well as the beta and gamma subunits of the IL-2 receptor. The secondary structure of the subunits, a highlight of the accompanying paper, are included in the illustration. An inset shows a zoomed-out view of an e ector T cell on a tumor cell to contextualize the main image.

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