This animation depicts the physiological and molecular events that occur during an acute inflammatory response through a sequential narrative. It illustrates the key cellular components of inflammation and symptoms that accompany it. By linking these mechanisms to recognizable physiological reactions, the animation provides an overview of inflammation at an appropriate level for the target audience. The narrative uses a pixel game-inspired scene as a framing device to introduce the narrative to viewers with playful, recognizable imagery. The molecular environment is stylized as a simplified, aqueous environment to reduce cognitive load.