The engineered F10 immunocytokine is composed of an F10 antibody linked to interleukin-2 (IL-2). The structure of the immunocytokine favors the binding of IL-2 to the IL-2 receptor heterodimer on e ector T cells, which triggers a pathway that promotes antitumor activity. This illustration depicts this interaction in an immersive tumor cell environment. The illustration was created for a journal cover, and molecule colors were chosen to align with the accompanying paper’s figure legend. The anatomy of the immunocytokine is labeled, as well as the beta and gamma subunits of the IL-2 receptor. The secondary structure of the subunits, a highlight of the accompanying paper, are included in the illustration. An inset shows a zoomed-out view of an e ector T cell on a tumor cell to contextualize the main image.